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General

Although there are other ways to analyze DNA, we use a noninvasive, cheek swab to collect buccal (cheek cells). The swab is easy to use and only takes about a minute to collect enough DNA for processing.
Your DNA is the blueprint for all the instructions in your body. Knowing your genetic results will enable you to live optimally and interact with your genes for their best way to function.
It’s easy! Rinse your mouth out twice to be sure you don't have anything in your mouth except your teeth. Open the swab packaging and rub the swab on the inside of your mouth, all around your cheek, flipping the swab to get cells on both sides of the swab surface, approximately 20 times back and forth on the inside of each cheek.
No. Avoid brushing your teeth immediately before swabbing because you don't want the bristles to catch the cells we are trying to get.
We cannot process samples with blood. If there is blood on your sample please safely discard the swab and give us a call so that we can send you a new kit.
It is our goal to complete your report as quickly as possible. The entire procedure, including shipping and individualized report, may take up to three weeks. Depending on the quality of the sample obtained, it can take between 3-6 weeks in the lab. The full sequencing process takes additional time because of the data we collect to cross-reference and ensure accuracy.
If we have any challenges processing your sample, we will contact you to provide you with an update, and send you a new swab if needed.
Just once. Your genes don't change. There are extremely rare occurrences of mutations, and it is not likely that you have one.
Groundwork for new companies involved in biotechnology, healthcare, environmental sciences, life sciences, needs. The SG lab features full sequence technology and equipment originally designed and used for biosimilar drug manufacturing. Our group of molecular biologists, scientists and educators at SG continue to perform research and development for current and future genetic tests.
It can be, providing the wrong stimuli for receptors can create little to no communication along the pathway. It's like turning on a switch that is not connected the electrical circuit. Your body may not understand the signals or may overcompensate if the signal is too high. Compensating can appear in the forms of hunger, low energy, injury, etc.
Yes. While Simply Fit is presented as a weight loss test, we know these genes can increase performance for all levels of athletes. Exercising too much may create diminished return or cause your body to get into compensatory mode. If you do it right, you don't have to do it as much.

The genes we analyze directly influence how your body absorbs and metabolizes fat, how your body reacts to exercise and diet and how you can best manage weight gain/loss.

  • ADRB2 positions 16 and 27 Beta-2 Adrenergic Receptor—These positions on this gene are commonly researched to learn about obesity. The results from this gene can explain what sources of energy your body uses the most efficiently and how you process and store fats and carbohydrates.
  • ADRB3-64 Beta-3 Adrenergic Receptor—Overall energy expenditure, including exercise, stimulates these receptors, which regulate the breakdown of fat. The variations on this gene allow us to determine how much exercise your body needs to most efficiently breakdown fat.
  • PPARG-12 Peroxisome Proliferator Receptor Gamma—is a nuclear receptor that can have a dominating role over the metabolic processes controlled by the nervous system. PPARG regulates how the body metabolizes fat and carbohydrates and how fat is stored in the body. It also stimulates fat uptake. PPARG is also associated with glucose sensitivity, insulin problems and resistance to weight loss. The degree to which you may experience these ailments is determined by the unique variations.
We chose these genes because they allow us to understand some of the key factors in the metabolic processes. Each different variation has a different set of instructions for the body. By knowing an individual's polymorphisms, we learn how the genes respond to certain stimuli and how best to work with them. This knowledge enables us to create the ideal program, catered to the way your genes will respond to exercise, nutrition and supplementation. Not only have these genes been the most heavily researched genes assigned to the obesity gene map, they are also all important factors in identifying how to make the most of the time spent exercising and what nutritional plan to follow.
We have seen overlap in certain cases. Be mindful though, that gender and lifestyle can play a large role in how your body functions and looks compared to anyone else's. The way humans have evolved over the centuries is partially responsible for the overlap we see. As humans had to adapt to cold weather and harsh conditions, so did their genes in order to store fat as a way to keep warm. We have carried and passed these genes along, but our lifestyle and society has vastly changed, so that these genetic variants are no longer vital for our survival. There is also a mathematical explanation. There are a finite number of possibilities; three possible variations exist. Therefore, we expect overlap to occur because there are a limited number of possible combinations that exist.
With these genes we are able to gather substantial information for you to make a difference and lose weight, without letting the test become too expensive. [We fully sequence your genetic material so that we can be sure you are getting the most accurate information. And you never have to do it again because your genes do not change!]
We have combined research, years of dedication and expertise in science, diet, nutrition, exercise and supplements to develop the results for your individual genotype. Clear and simple: DO, EAT, TAKE. The plan developed by Simplified Genetics guides you step-by-step to achieve your ideal weight and level of fitness. After we analyze your DNA and receive the lab results, we review your unique variations independently and also in context with the rest of your genotype, which makes Simply Fit the most comprehensive on the market.
Metabolic typing looks solely at the physical properties associated with metabolism to identify a healthy diet for you. A simple questionnaire is analyzed to gather data about your energy levels, your resting heart rate or metabolic rate. Simplified Genetics tests your DNA. It doesn't get more scientific than that.
You receive personalized, thorough results with specific, actionable information on what exercise to DO, foods to EAT and supplements to TAKE. No more fad diets to try, pills to buy or books to read. One test, one time. It’s not about working out.
Exercising and eating right make you healthy. But the question to ask is; "What exercise and diet are right for me as a unique individual?" If you want to maximize your results and reach your optimal weight as quickly as possible, your genes are the key.

Science

Your DNA sequence is like a code, made from unique combinations of just four base nucleotides (A,C,T,G). Each combination creates a unique set of instructions for each function in your body. The change from ‘A’ to ‘C’ creates a different code and therefore a different set of instructions.
The single nucleotide polymorphism (SNP), pronounced, “snip”, is the change from one nucleotide to another along your sequence. Your polymorphisms are responsible for your individual differences, and can vary from one person to another. The SNP is how we each have our own set of unique characteristics.
Epigenetics is the interaction between elements of your environment such as diet and stress, which act as epigenetic signals, and can change the physical expression of your genes. Your genes don't change, but the way they are expressed can.
Simplified Genetics uses full sequencing because it is the only way to ensure accurate results. Full sequencing examines full strands of DNA, analyzes larger sections of genetic material, and produces accurate results. A SNP analysis is simply a diagnostic tool that identifies only one base pair of nucleotides. While it is less costly, SNP analysis may produce inconsistent results.
We start by collecting your buccal cells inside your cheek. You swab the inside of your mouth, for about one minute and send it to our lab. After your DNA is extracted from the swab, multiple steps are taken to identify your sequence and ultimately, the polymorphism on the gene marker.